Emergence of spiral wave activity in a mechanically heterogeneous reaction-diffusion-mechanics system.
نویسندگان
چکیده
We perform a numerical study of emergent spiral wave activity in a two-dimensional reaction-diffusion-mechanics medium with a regional inhomogeneity in active and passive mechanical properties. We find that self-sustaining spiral wave activity emerges for a wide range of mechanical parameters of the inhomogeneity via five mechanisms. We classify these mechanisms, relate them to parameters of the inhomogeneity, and discuss how these results can be applied to understand the onset of cardiac arrhythmias due to regional mechanical heterogeneity.
منابع مشابه
New Mechanism of Spiral Wave Initiation in a Reaction-Diffusion-Mechanics System
Spiral wave initiation in the heart muscle is a mechanism for the onset of dangerous cardiac arrhythmias. A standard protocol for spiral wave initiation is the application of a stimulus in the refractory tail of a propagating excitation wave, a region that we call the "classical vulnerable zone." Previous studies of vulnerability to spiral wave initiation did not take the influence of deformati...
متن کاملModeling cardiac mechano-electrical feedback using reaction-diffusion-mechanics systems
In many practically important cases, wave propagation described by the reaction-diffusion equation initiates deformation of the medium. Mathematically, such processes are described by coupled reactiondiffusion-mechanics (RDM) systems. RDM systemswere recently used to study the effects of deformation on wave propagation in cardiac tissue, so called mechano-electrical feedback (MEF). In this arti...
متن کاملMechano-electric Feedback and Initiation of Cardiac Arrhythmias
The heart beat is controlled by electrical excitation waves which propagate through the heart and initiate cardiac contraction. Contraction of the heart also affects the process of wave propagation resulting in a complex global feedback phenomenon known as mechanoelectrical feedback (MEF). MEF has been studied in electrophysiology for well over a century and may have both pro-arrhythmic and arr...
متن کاملDrift and breakup of spiral waves in reaction-diffusion-mechanics systems.
Rotating spiral waves organize excitation in various biological, physical, and chemical systems. They underpin a variety of important phenomena, such as cardiac arrhythmias, morphogenesis processes, and spatial patterns in chemical reactions. Important insights into spiral wave dynamics have been obtained from theoretical studies of the reaction-diffusion (RD) partial differential equations. Ho...
متن کاملWave Propagation and Fundamental Solution of Initially Stressed Thermoelastic Diffusion with Voids
The present article deals with the study of propagation of plane waves in isotropic generalized thermoelastic diffusion with voids under initial stress. It is found that, for two dimensional model of isotropic generalized thermoelastic diffusion with voids under initial stress, there exists four coupled waves namely, P wave, Mass Diffusion (MD) wave, thermal (T) wave and Volume Fraction (VF) wa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Physical review letters
دوره 108 22 شماره
صفحات -
تاریخ انتشار 2012